The most common and most likely answer to this crossword clue is the 6 letter word UNEASE
I've seen this crossword clue in The Times
U
N
E
A
S
E
More clues leading to the result UNEASE
- Disquiet coming from misfortune, as expected
- Difficulty presumably felt by crowned head?
- Ensnared by misfortune, a senator feeling nervous
- Discontent in leaving EU – insane rubbish!
- Northeast area cuts employment bringing apprehension
- Trouble most of the month for centre of Basel
- Misfortune, as expected, brings discomfort with it
- Apprehension caused by universal joints, we hear
- A French female swallowing rough sea causing apprehension
- A French flirt has no time for worry
Buddy explains!
The straight part
We know that "Difficulty" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case difficulty = unease.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does UNEASE mean?
UNEASE noun- Trouble; misery; a feeling of disquiet or concern.
- To make uneasy or uncomfortable