Cryptic crossword clue
Dirty Harry: much of the intention picked up as agitation of the heart 10

The most common and most likely answer to this crossword clue is the 10 letter word ARRHYTHMIA

I've seen this crossword clue in Independent
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Buddy explains!

The straight part
We know that "agitation of the heart" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case agitation of the heart = arrhythmia.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ARRHYTHMIA mean?

ARRHYTHMIA noun
  1. An irregular heartbeat.
  2. A disease entity involving such beats, such as atrial fibrillation, ventricular tachycardia, AV nodal reentrant tachycardia, or others.

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