Cryptic crossword clue
Disaffection of irregular soldiers captured by 26 12

The most common and most likely answer to this crossword clue is the 12 letter word ESTRANGEMENT

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Buddy explains!

The straight part
We know that "Disaffection" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case disaffection = estrangement.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ESTRANGEMENT mean?

ESTRANGEMENT noun
  1. The act of estranging; the act of alienating; alienation.
  2. The state of being alien; foreign, non-native.

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