Cryptic crossword clue
Disagree with switch before 13 6

The most common and most likely answer to this crossword clue is the 6 letter word DIFFER

I've seen this crossword clue in The Guardian
D
I
F
F
E
R

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The straight part
We know that "Disagree with" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case disagree with = differ.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DIFFER mean?

DIFFER verb
  1. Not to have the same traits or characteristics; to be unalike or distinct.
  2. (people, groups, etc.) To have diverging opinions, disagree.
  3. To be separated in quantity.

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