Cryptic crossword clue
Disappointed Ed — his wench wanted to go topless 12

The most common and most likely answer to this crossword clue is the 12 letter word DISENCHANTED

I've seen this crossword clue in The Guardian
D
I
S
E
N
C
H
A
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T
E
D

Buddy explains!

The straight part
We know that "Disappointed" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case disappointed = disenchanted.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DISENCHANTED mean?

DISENCHANTED verb
  1. (of a person) To free from illusion, false belief or enchantment; to undeceive or disillusion.
  2. (of a person) To disappoint.
  3. (of a thing) To remove a spell or magic enchantment from.

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