Cryptic crossword clue
Displaying guile, Oscar is terribly irreverent 12

The most common and most likely answer to this crossword clue is the 12 letter word SACRILEGIOUS

I've seen this crossword clue in The Guardian
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Buddy explains!

The straight part
We know that "irreverent" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case irreverent = sacrilegious.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SACRILEGIOUS mean?

SACRILEGIOUS adjective
  1. Committing sacrilege; acting or speaking very disrespectfully toward what is held to be sacred.

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