The most common and most likely answer to this crossword clue is the 10 letter word STIR-CRAZY
I've seen this crossword clue in Financial Times
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More clues leading to the result STIR-CRAZY
Buddy explains!
The straight part
We know that "distraught because of prolonged confinement" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case distraught because of prolonged confinement = stir-crazy.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does STIR-CRAZY mean?
STIR-CRAZY adjective- Of a prisoner, mentally unbalanced due to prolonged incarceration.
- (by extension) Restless, uncomfortable, or impatient due to inactivity or confinement.