Cryptic crossword clue
Do add a dose — a shot — and absolutely no more 4,2,1,4

The most common and most likely answer to this crossword clue is the 4 plus 2 plus 1 plus 4 letter word DEAD AS A DODO

I've seen this crossword clue in The Times
D
E
A
D
A
S
A
D
O
D
O

Buddy explains!

The straight part
We know that "absolutely no more" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case absolutely no more = dead as a dodo.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

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