Cryptic crossword clue
Do in marquee finally finishes when public house axes it, sealing off area 10

The most common and most likely answer to this crossword clue is the 10 letter word ASPHYXIATE

I've seen this crossword clue in The Times
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Buddy explains!

The straight part
We know that "Do in" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case do in = asphyxiate.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ASPHYXIATE mean?

ASPHYXIATE verb
  1. To smother or suffocate someone.
  2. To be smothered or suffocated.

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