Cryptic crossword clue
Do start puzzle 8

The most common and most likely answer to this crossword clue is the 8 letter word CONFOUND

I've seen this crossword clue in Financial Times
C
O
N
F
O
U
N
D

Buddy explains!

The straight part
We know that "puzzl" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case puzzl = confound.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does CONFOUND mean?

CONFOUND noun
  1. A confounding variable.
CONFOUND verb
  1. To perplex or puzzle.
  2. To fail to see the difference; to mix up; to confuse right and wrong.
  3. To make something worse.
  4. To combine in a confused fashion; to mingle so as to make the parts indistinguishable.
  5. To cause to be ashamed; to abash.
  6. To defeat, to frustrate, to thwart.
  7. To damn (a mild oath).
  8. To bring to ruination.
  9. To stun, amaze

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