Cryptic crossword clue
Doctor from East keeps coming upon strange chemical substance 4,8

The most common and most likely answer to this crossword clue is the 4 plus 8 letter word RING COMPOUND

I've seen this crossword clue in Independent
R
I
N
G
C
O
M
P
O
U
N
D

Buddy explains!

The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
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