The most common and most likely answer to this crossword clue is the 10 letter word PICK-ME-UP
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More clues leading to the result PICK-ME-UP
Buddy explains!
The straight part
We know that "shot in the arm" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case shot in the arm = pick-me-up.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does PICK-ME-UP mean?
PICK-ME-UP noun- A drink, especially an alcoholic one, taken as a stimulant or sometimes as a hangover cure; a restorative, tonic or bracer.