The most common and most likely answer to this crossword clue is the 8 letter word HASHEESH
I've seen this crossword clue in Independent
H
A
S
H
E
E
S
H
Buddy explains!
The straight part
We know that "a different drug (from those already mentioned)" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case a different drug (from those already mentioned) = hasheesh.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.