The most common and most likely answer to this crossword clue is the 6 letter word MEDIAL
M
E
D
I
A
L
More clues leading to the result MEDIAL
Buddy explains!

The straight part
We know that "situated in middle" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case situated in middle = medial.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does MEDIAL mean?
MEDIAL noun- Any of various things that occur in the middle.
- Of or pertaining to a mean or average.
- In or near the middle; not at either end.
- Pertaining to the inside; closer to the midline.
- Closer to the addressee.
- (of a consonant) Central: produced when air flows across the center of the mouth over the tongue.