The most common and most likely answer to this crossword clue is the 10 letter word PLUGGED-IN
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Buddy explains!

The straight part
We know that "clued-up" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case clued-up = plugged-in.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does PLUGGED-IN mean?
PLUGGED-IN adjective- (of an electric device) With its plug properly connected to the electric plug socket.
- (by extension) Fully aware; in a state of keeping up with current information about a topic; engaged wholeheartedly in a task or cause