Cryptic crossword clue
Dreadfully stoned again, getting annoyed 11

The most common and most likely answer to this crossword clue is the 11 letter word ANTAGONISED

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Buddy explains!

The straight part
We know that "annoyed/stone" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case annoyed/stone = antagonised.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ANTAGONISED mean?

ANTAGONISED verb
  1. To work against; to oppose (especially to incite reaction)
ANTAGONISED adjective
  1. (especially describing a muscle) Having been acted on by antagonistic forces.
  2. (of a person or group) Having been aggravated or made into an enemy.

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