The most common and most likely answer to this crossword clue is the 7 letter word LACTOSE
I've seen this crossword clue in The Guardian
L
A
C
T
O
S
E
More clues leading to the result LACTOSE
- Doctor locates possible cause of problem for IBS sufferers
- Introduce law to reduce sugar
- Sugar said to be down in digits?
- Drop enthralling pretence — some can’t tolerate it
- Be like Lear’s Pobble, say, sweet thing
- Performance in ditch not tolerated by some
- Excited cat enters tank to get milk extract
- Doctor locates source of food intolerance?
- Sugar shortage members reported
Buddy explains!
The straight part
We know that "some can’t tolerate it/some can’t tolerate it" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case some can’t tolerate it/some can’t tolerate it = lactose.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does LACTOSE mean?
LACTOSE noun- The disaccharide sugar of milk and dairy products, C12H22O11, a product of glucose and galactose used as a food and in medicinal compounds.