Cryptic crossword clue
Drug an old curse on friend of Pooh 6

The most common and most likely answer to this crossword clue is the 6 letter word ROOFIE

I've seen this crossword clue in Financial Times
R
O
O
F
I
E

Buddy explains!

The straight part
We know that "Drug" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case drug = roofie.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ROOFIE mean?

ROOFIE noun
  1. (often plurale tantum) The date rape drug flunitrazepam.
  2. (by extension) Any drug designed to make someone drowsy or disoriented.
ROOFIE verb
  1. To put roofies in; to spike with roofies.
  2. To cause someone to (usually unknowingly) ingest roofies.

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