Cryptic crossword clue
Drug found in quantities in these vessels 8

The most common and most likely answer to this crossword clue is the 8 letter word GALLEONS

I've seen this crossword clue in The Daily Telegraph
G
A
L
L
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S

Buddy explains!

The straight part
We know that "vessels" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case vessels = galleons.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does GALLEONS mean?

GALLEONS noun
  1. A large, three masted, square rigged sailing ship with at least two decks.

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