Cryptic crossword clue
Drug gets boss out of his box during film 8

The most common and most likely answer to this crossword clue is the 8 letter word CAFFEINE

I've seen this crossword clue in Independent
C
A
F
F
E
I
N
E


Buddy explains!

The straight part
We know that "Drug" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case drug = caffeine.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does CAFFEINE mean?

CAFFEINE noun
  1. An alkaloid, C8H10N4O2, found naturally in tea and coffee plants which acts as a mild stimulant on the central nervous system.

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