Cryptic crossword clue
Drug given to control group initially producing minor changes 9

The most common and most likely answer to this crossword clue is the 9 letter word REHASHING

I've seen this crossword clue in Financial Times
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Buddy explains!

The straight part
We know that "producing minor changes" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case producing minor changes = rehashing.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does REHASHING mean?

REHASHING verb
  1. To repeat with minor variation.
  2. To analyze a prior contentious or embarrassing event.
  3. To recompute the structure of a hash table, taking into account any newly added items.
REHASHING noun
  1. The act by which something is rehashed.

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