Cryptic crossword clue
Drug, helper outside ward had consumed at first by mistake 12

The most common and most likely answer to this crossword clue is the 12 letter word ACCIDENTALLY

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Buddy explains!

The straight part
We know that "by mistake" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case by mistake = accidentally.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ACCIDENTALLY mean?

ACCIDENTALLY adverb
  1. In an accidental manner; by chance, unexpectedly.
  2. Unintentionally.

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