Cryptic crossword clue
Drug swallowed, now losing weight: I’m laughing! 8

The most common and most likely answer to this crossword clue is the 8 letter word ATENOLOL

A
T
E
N
O
L
O
L

Buddy explains!

The straight part
We know that "Drug" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case drug = atenolol.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ATENOLOL mean?

ATENOLOL noun
  1. A beta blocker used mainly to treat angina and high blood pressure.

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