The most common and most likely answer to this crossword clue is the 10 letter word DISTRAUGHT
I've seen this crossword clue in The Guardian
D
I
S
T
R
A
U
G
H
T
More clues leading to the result DISTRAUGHT
- Daughter is instructed about Rex, being very worried
- Slug sandwiches infiltrating Spanish tapas starters, frantic!
- Sit awkwardly in breeze, becoming upset
- In drink, German is beside himself
- Is Trump beginning to be trapped in current upset?
- First in cold blast to become agitated
- Drug that is suspect makes one deeply agitated
- Frantic swallow perhaps claims highest spot
- Getting into beer, one good person raving
- Detectives given instruction to arrest Republican in a state
Buddy explains!

The straight part
We know that "deeply agitated" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case deeply agitated = distraught.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does DISTRAUGHT mean?
DISTRAUGHT adjective- Deeply hurt, saddened, or worried; distressed.
- Mad; insane.