The most common and most likely answer to this crossword clue is the 9 letter word EPHEDRINE
I've seen this crossword clue in The Daily Telegraph
E
P
H
E
D
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More clues leading to the result EPHEDRINE
Buddy explains!

The straight part
We know that "Drug" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case drug = ephedrine.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does EPHEDRINE mean?
EPHEDRINE noun- An alkaloid, found in some species of Ephedra shrubs (or prepared synthetically).
- A medication whose active ingredient is ephedrine, used as a sympathomimetic drug.