Cryptic crossword clue
Drug trifle over sports energy drinks 6

The most common and most likely answer to this crossword clue is the 6 letter word PEYOTE

P
E
Y
O
T
E

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The straight part
We know that "Drug" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case drug = peyote.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does PEYOTE mean?

PEYOTE noun
  1. A small, spineless cactus (Lophophora williamsii) found from southwest United States to central Mexico that produces buttonlike tubercles that can be chewed for its psychedelic effect, primarily from the drug mescaline.
  2. A mescal button produced by the plant.

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