The most common and most likely answer to this crossword clue is the 6 letter word UPPERS
I've seen this crossword clue in The Guardian
U
P
P
E
R
S
Buddy explains!
The straight part
We know that "Drugs?/Being on these, one would be broke (6)" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case drugs?/being on these, one would be broke (6) = uppers.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does UPPERS mean?
UPPERS noun- A stimulant, such as amphetamine, that increases energy and decreases appetite.
- The upper portion of something
- Someone with higher social standing
- That which is higher, contrasted with the lower.
- A spiritual passageway through which consciousness can reach a higher dimension.