Cryptic crossword clue
Drugs first work, then a setback 7

The most common and most likely answer to this crossword clue is the 7 letter word OPIATES

O
P
I
A
T
E
S


Buddy explains!

The straight part
We know that "Drugs" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case drugs = opiates.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does OPIATES mean?

OPIATES noun
  1. A drug, hormone or other substance derived from or related to opium.
  2. Something that dulls the senses and induces a false and unrealistic sense of contentment.
OPIATES verb
  1. To treat with an opiate drug.

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