Cryptic crossword clue
Drunk, orders a nip and decides things irrevocably 10

The most common and most likely answer to this crossword clue is the 10 letter word PREORDAINS

P
R
E
O
R
D
A
I
N
S

Buddy explains!

The straight part
We know that "decides things irrevocably" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case decides things irrevocably = preordains.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does PREORDAINS mean?

PREORDAINS verb
  1. To determine the fate of something in advance.

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