Cryptic crossword clue
Duck PE in school, if really tired 6

The most common and most likely answer to this crossword clue is the 6 letter word POOPED

I've seen this crossword clue in The Guardian
P
O
O
P
E
D

Buddy explains!

The straight part
We know that "really tired" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case really tired = pooped.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does POOPED mean?

POOPED verb
  1. To make a short blast on a horn
  2. To break wind.
  3. To defecate.
POOPED verb
  1. To tire, exhaust. Often used with out.
POOPED verb
  1. To break seawater with the poop of a vessel, especially the poop deck.
  2. To embark a ship over the stern.
POOPED adjective
  1. Tired; exhausted.
  2. Fitted or furnished with a poop.
  3. Having had a wave come over the stern from abaft.

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