Cryptic crossword clue
During filming entire crew’s performance relies initially on him 12

The most common and most likely answer to this crossword clue is the 12 letter word SCREENWRITER

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The cryptic/wordplay part
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What does SCREENWRITER mean?

SCREENWRITER noun
  1. One who writes for the screen, who writes drama for film or television; especially a professional who knows the conventions appropriate to such work.

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