Cryptic crossword clue
During holiday you head off westward, away from normal environment 2,5

The most common and most likely answer to this crossword clue is the 2 plus 5 letter word IN VACUO

I've seen this crossword clue in The Guardian
I
N
V
A
C
U
O

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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

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