The most common and most likely answer to this crossword clue is the 9 letter word HOMEGIRLS
H
O
M
E
G
I
R
L
S
Buddy explains!

The straight part
We know that "Americans in neighbourhood?" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case americans in neighbourhood? = homegirls.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does HOMEGIRLS mean?
HOMEGIRLS noun- A female friend.
- A female co-member of a gang.