Cryptic crossword clue
Dying CO leaves instruction

The most common and most likely answer to this crossword clue is the 6 letter word ACHING

I've seen this crossword clue in The Guardian
A
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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ACHING mean?

ACHING verb
  1. To suffer pain; to be the source of, or be in, pain, especially continued dull pain; to be distressed.
  2. To cause someone or something to suffer pain.
ACHING noun
  1. The feeling of an ache; a dull pain.
ACHING adjective
  1. That aches; continuously painful.

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