Cryptic crossword clue
E-number? Notice it in unpleasant joint 8

The most common and most likely answer to this crossword clue is the 8 letter word ADDITIVE

I've seen this crossword clue in The Guardian
A
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Buddy explains!

The straight part
We know that "E-number?" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case e-number? = additive.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ADDITIVE mean?

ADDITIVE noun
  1. A substance added to another substance or product to produce specific properties in the combined substance.
  2. (grammar) A word or phrase that adds something, such as also, even, or nor.
ADDITIVE adjective
  1. Pertaining to addition; that can be, or has been, added.
  2. (of a function, etc.) That is distributive over addition.
  3. (of a group, semigroup, etc.) Whose operator is identified as addition.
  4. Pertaining to chemical addition.
  5. Of or pertaining to genes (or the interaction etc. of such genes) which govern the same trait and whose effects work together on the phenotype.

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