The most common and most likely answer to this crossword clue is the 5 letter word EYRIE
I've seen this crossword clue in The Times
E
Y
R
I
E
More clues leading to the result EYRIE
- Eponymous heroine saves island home for birds
- Dictator’s sinister observation post?
- Heroine Jane securing current high-rise retreat
- Observer guards river with one bird's nest
- Noise coming from ghostly and isolated place
- Jane keeps island home for birds
- Eagle’s attribute seen around river and island nest
- Remote spot Yankee’s found in going to N Ireland
- Lofty home where Providence is in view
- Jane tours one highly isolated position
Buddy explains!

The straight part
We know that "nest" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case nest = eyrie.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does EYRIE mean?
EYRIE noun- The nest of a bird of prey.
- Any high and remote but commanding place.