Cryptic crossword clue
Earl’s angry after last of men in gang ran through 10

The most common and most likely answer to this crossword clue is the 10 letter word SQUANDERED

I've seen this crossword clue in The Guardian
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The straight part
We know that "ran through" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case ran through = squandered.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SQUANDERED mean?

SQUANDERED verb
  1. To waste, lavish, splurge; to spend lavishly or profusely; to dissipate.
  2. To scatter; to disperse.
  3. To wander at random; to scatter.

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