The most common and most likely answer to this crossword clue is the 11 letter word EDIFICATION
I've seen this crossword clue in The Daily Telegraph
E
D
I
F
I
C
A
T
I
O
N
More clues leading to the result EDIFICATION
Buddy explains!

The straight part
We know that "instruction" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case instruction = edification.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does EDIFICATION mean?
EDIFICATION noun- The act of edifying, or the state of being edified or improved; a building process, especially morally, emotionally, or spiritually
- A building or edifice.