Cryptic crossword clue
Edna anonymously appearing in Cornish resort to get tranquillisers 9

The most common and most likely answer to this crossword clue is the 9 letter word SEDATIVES

I've seen this crossword clue in The Daily Telegraph
S
E
D
A
T
I
V
E
S

Buddy explains!

The straight part
We know that "tranquillisers" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case tranquillisers = sedatives.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SEDATIVES mean?

SEDATIVES noun
  1. An agent or drug that sedates, having a calming or soothing effect, or inducing sleep.

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