Cryptic crossword clue
Egghead uncle a little upset 12

The most common and most likely answer to this crossword clue is the 12 letter word INTELLECTUAL

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Buddy explains!

The straight part
We know that "Egghead" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case egghead = intellectual.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does INTELLECTUAL mean?

INTELLECTUAL noun
  1. An intelligent, learned person, especially one who discourses about learned matters.
  2. The intellect or understanding; mental powers or faculties.
INTELLECTUAL adjective
  1. Belonging to, or performed by, the intellect; mental or cognitive.
  2. Endowed with intellect; having the power of understanding; having capacity for the higher forms of knowledge or thought; characterized by intelligence or mental capacity
  3. Suitable for exercising the intellect; formed by, and existing for, the intellect alone; perceived by the intellect
  4. Relating to the understanding; treating of the mind.
  5. Spiritual.

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