The most common and most likely answer to this crossword clue is the 7 letter word TOLUENE
I've seen this crossword clue in The Daily Telegraph
T
O
L
U
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Buddy explains!

The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does TOLUENE mean?
TOLUENE noun- A colourless, inflammable liquid hydrocarbon, methylbenzene, CH3.C6H5, used as a solvent, in high-octane fuels and in the production of many chemical compounds.