Cryptic crossword clue
Empathized without the shakes after swallowing a tranquillizer 8

The most common and most likely answer to this crossword clue is the 8 letter word DIAZEPAM

D
I
A
Z
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M

Buddy explains!

The straight part
We know that "tranquillizer" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case tranquillizer = diazepam.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DIAZEPAM mean?

DIAZEPAM noun
  1. A tranquilizing muscle relaxant drug (trademark Valium) used chiefly to relieve anxiety.

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