The most common and most likely answer to this crossword clue is the 8 letter word ABORTION
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The straight part
We know that "End" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case end = abortion.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does ABORTION mean?
ABORTION noun- The expulsion from the womb of a foetus or embryo before it is fully developed, with loss of the foetus; either naturally as a spontaneous abortion (now usually called a miscarriage), or deliberately as an induced abortion.
- An aborted foetus; an abortus.
- A misshapen person or thing; a monstrosity.
- Failure or abandonment of a project, promise, goal etc.
- Arrest of development of any organ, so that it remains an imperfect formation or is absorbed.
- The cessation of an illness or disease at a very early stage.