The most common and most likely answer to this crossword clue is the 6 letter word ENMESH
I've seen this crossword clue in Financial Times
E
N
M
E
S
H
More clues leading to the result ENMESH
- Tangle with men he’s upset
- Net product of eleven midsize Scottish banks
- Nurse, occasionally I’m tense on a little horse and trap
- End of life, with me in NHS organisation tangle
- Involve outsiders to explain chaos reported by drunkard?
- What about wild men’s snarl?
- She and men get involved – become engaged
- Get involved in open game as — oh! — everything in first half quite forgettable
- Catch he-men cavorting around top of stage
- Men she gets mixed up in tangle
Buddy explains!

The straight part
We know that "tangle" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case tangle = enmesh.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does ENMESH mean?
ENMESH verb- To mesh; to tangle or interweave in such a manner as not to be easily separated, particularly in a mesh or net like manner.
- To involve in such complications as to render extrication difficult
- To involve in difficulties.