Cryptic crossword clue
End of road with Sam’s family maybe? People in a neighbourhood 8

The most common and most likely answer to this crossword clue is the 8 letter word DWELLERS

I've seen this crossword clue in Financial Times
D
W
E
L
L
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S

Buddy explains!

The straight part
We know that "People in a neighbourhood" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case people in a neighbourhood = dwellers.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DWELLERS mean?

DWELLERS noun
  1. An inhabitant of a specific place; an inhabitant or denizen.

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