Cryptic crossword clue
Enemy failing to take west of zone is a catalyst 6

The most common and most likely answer to this crossword clue is the 6 letter word ENZYME

I've seen this crossword clue in The Daily Telegraph
E
N
Z
Y
M
E


Buddy explains!

The straight part
We know that "a catalyst" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case a catalyst = enzyme.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ENZYME mean?

ENZYME noun
  1. A globular protein that catalyses a biological chemical reaction.
  2. Leavened bread, as opposed to azyme

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