Cryptic crossword clue
Energy drink first, then grub cooked for one not responding to treatment 8

The most common and most likely answer to this crossword clue is the 8 letter word SUPERBUG

I've seen this crossword clue in The Times
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Buddy explains!

The straight part
We know that "one not responding to treatment" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case one not responding to treatment = superbug.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SUPERBUG mean?

SUPERBUG noun
  1. A strain of bacteria that is resistant to many antibiotics.
  2. Any pathogen resistant to many, even all, of the biocides or other agents used to treat similar pathogens.
  3. An invasive insect, Bemisia tabaci, that is a major pest of vegetable crops, both directly and as a virus vector.

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