The most common and most likely answer to this crossword clue is the 11 letter word OESOPHAGEAL
I've seen this crossword clue in The Guardian
O
E
S
O
P
H
A
G
E
A
L
More clues leading to the result OESOPHAGEAL
Buddy explains!

The straight part
We know that "of a tube" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case of a tube = oesophageal.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does OESOPHAGEAL mean?
OESOPHAGEAL adjective- Of or pertaining to the esophagus.