Cryptic crossword clue
Energy source that’s unappealing, first off, then endlessly powerful 8

The most common and most likely answer to this crossword clue is the 8 letter word GLYCOGEN

I've seen this crossword clue in The Times
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Buddy explains!

The straight part
We know that "Energy source" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case energy source = glycogen.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does GLYCOGEN mean?

GLYCOGEN noun
  1. A polysaccharide that is the main form of carbohydrate storage in animals; converted to glucose as needed.

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