Cryptic crossword clue
Engineers smoke a lot at work, stifling resistance 10

The most common and most likely answer to this crossword clue is the 10 letter word TOOLMAKERS

I've seen this crossword clue in Financial Times
T
O
O
L
M
A
K
E
R
S

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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does TOOLMAKERS mean?

TOOLMAKERS noun
  1. A skilled machinist who makes and repairs tools.

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